Scientists have discovered a way that could help treat severe inflammation from an infectious mosquito-borne disease during outbreaks.
A team of researchers led by Professor Suresh Mahalingam at Griffith University’s Institute for Glycomics on the Gold Coast are developing ways to treat debilitating diseases caused by alphaviruses such as Chikungunya and Ross River virus. Their study is published this week in the journal Nature Microbiology.
Some mosquito-borne viruses cause severe joint and muscle inflammation, and there are no vaccines or specific drugs to treat the disease caused by these viruses.
Chikungunya virus (CHIKV), a re-emerging alphavirus responsible for several outbreaks worldwide in the past decade, causes debilitating joint inflammation and severe pain.
During acute infection with Chikungunya virus, scientists found that a molecular complex, known as the inflammasome, became activated in patients suffering acute signs of the disease.
“When we infected mice with Chikungunya, we found that a type of inflammasome known as NLRP3 was
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